Wound healing In Diabetic Conditions

posted Dec 24, 2015, 3:29 AM by SRamachandran igib   [ updated Dec 27, 2015, 11:04 PM ]
Wound healing is a normal biological process whereby the injured tissue regains its normal function through precisely and highly programmed overlapping phases. Any interference in any one or more stages of these events causes delayed/impaired wound. Several pathophysiological conditions play critical roles in delaying the process of wound repair. Diabetes is a highly prevalent chronic metabolic disorder characterized by high levels of blood glucose and delayed wound healing is one of the major complications associated with diabetes that quite often leads to traumatic lower extremity amputations and chronic wound ulcers. We have been trying to study factors behind the delayed wound closure during diabetes and have identified an altered miRNA signature during such delayed wound closure. This was accompanied by decreased levels of Dicer, the enzyme that is responsible for miRNA biogenesis. Also several wound healing specific genes were altered in the unhealed wound during diabetes. Results suggest that there might be a correlation between the altered miRNA signature and altered wound healing genes that might be responsible for prolonging wound closure during diabetes. In keratinocyte cells, Dicer inhibition prevented cell migration and affected wound closure in-vitro. Results suggest a potential role of miRNAs and Dicer during delayed wound closure and offer promise to address the issue of impaired wound healing. (Molecular Medicine. 2015, doi: 10.2119/molmed.2014.00186)