Heart disease is the leading cause for death in men and women. Early detection of heart attacks can be saving. In a collaborative work, Deepika Bhatnagar and her colleagues have developed a sensor to detect the antigen cardiac-Troponin I (cTnI). The technique uses Graphene quantum dots conjugated to antibody anti-cardiac Troponin I and fluorescence resonance energy transfer (FRET). The sensor is highly specific and shows negligible response to non-specific antigens. The sensor displayed a linear response to cTnI from 0.001 to 1000 ng/mL with a limit of detection of 0.192 pg/mL.
Bhatnagar D, Kumar V, Kumar A, Kaur I. Graphene quantum dots FRET based sensor for early detection of heart attack in human. Biosens Bioelectron. 2016 May 15;79:495-9. doi: 10.1016/j.bios.2015.12.083. Epub 2015 Dec 25. PubMed PMID: 26748366.
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